Abstract The abnormal structure of tumor vascular seriously hinders the delivery and deep penetration of drug in tumor therapy. Herein. an integrated and tumor microenvironment (TME)-responsive nanocarrier is designed. which can dilate vessle and improve the drug penetration by in situ releasing nitric oxide (NO). https://www.roneverhart.com/Corvette-Leather-Seat-Covers-Graphite-Standard-1984-1987/